SAB4501342

Anti-CARD10 antibody produced in rabbit

affinity isolated antibody

• 别名: CARD-containing MAGUK protein 3, CARD10, CARMA3, Carma 3, Caspase recruitment domain-containing protein 10
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 115 kDa
• 物種活性: mouse, human
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:1000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI登錄號: Q9BWT7
• UniProt登錄號: Q9BWT7
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CARD10(29775)

说明

一般說明

Anti-CARD10 antibody detects endogenous levels of total CARD10 protein.

CARD10 (caspase recruitment domain-containing protein 10) is an important BCL10 (B-cell CLL/lymphoma 10) interactor. It is a member of membrane-associated guanylate kinase family. It is mapped to human chromosome 22q13.1. The CARD10 protein has 1032 amino acids with an estimated molecular weight of 116 kDa. It consists of five putative functional domains, an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal tripartite structure consisting of a PDZ (post synaptic density protein (PSD95), drosophila disc large tumor suppressor (Dlg1) and zonula occludens-1 protein) domain, an SH3 (SRC homology 3 domain) domain, and a GUK (guanylate kinases) domain with homology to guanylate kinase. In several adult tissues, including heart, kidney, and liver, it is expressed as a 4.4-kilobase transcript.

免疫原

The antiserum was produced against synthesized peptide derived from human CARD10.

Immunogen Range: 481-530

生化／生理作用

CARD10 (Caspase recruitment domain-containing protein 10) helps to arrange signaling complexes at plasma membrane. It also serves as a molecular scaffold for the assembly of a B-cell CLL/lymphoma 10 (BCL10) signaling complex that activates NF-κB (nuclear factor-κB).

特點和優勢

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外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable