生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 69 kDa
种属反应性
human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:20000
immunofluorescence: 1:100-1:500
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COL13A1(1305)
一般描述
The COL13A1 (collagen type XIII α-1 chain) gene is mapped to human chromosome 10q22.1. It codes for the α-chain of a group of non-fibrillar collagen. The protein is homotrimeric containing a single transmembrane region with intracellular and extracellular domains. The ectodomain contains three alternating collagenous and non-collagenous domains. COL13A1 is expressed in the muscle motor endplate. Anti-Collagen XIII α1 Antibody detects endogenous levels of total Collagen XIII α1 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Collagen XIII alpha1.
Immunogen Range: 641-690
Immunogen Range: 641-690
生化/生理作用
Collagen XIII α1 (COL13A1) is an oncogene, promoting invasion in cancer. Upregulation of COL13A1 gene is observed in bladder cancer. COL13A1 is associated with neuromuscular junction organization. Mutation in the gene leads to myasthenic disorder.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Diagnostic and prognostic role of urinary collagens in primary human bladder cancer
Miyake M, et al.
Cancer Science, 108(11), 2221-2228 (2017)
Congenital myasthenic syndrome type 19 is caused by mutations in COL13A1, encoding the atypical non-fibrillar collagen type XIII alpha1 chain
Logan CV, et al.
American Journal of Human Genetics, 97(6), 878-885 (2015)
Type XIII collagen and some other transmembrane collagens contain two separate coiled-coil motifs, which may function as independent oligomerization domains
Latvanlehto A, et al.
The Journal of Biological Chemistry, 278(39), 37590-37599 (2003)
Clinical and genetic basis of congenital myasthenic syndromes
PVS DeSouza, et al.
Arquivos de Neuro-Psiquiatria, 74(9), 750-760 (2016)
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