生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
17 kDa
物種活性
rat, mouse, human
濃度
1.0 mg/mL
技術
western blot: 1:500-1:1000 (Cell Lysate)
同型
IgG
登錄號
NP_005175.2
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pThr79)
基因資訊
human ... CALM3(808)
一般說明
Calmodulin 3 (CALM3) encodes calmodulin (CaM) protein 3 which is expressed five folds more than CALM1 and CALM2. CALM3 promoter has high GC content and no TATA box like that of housekeeping gene. CALM3 contains several pro-alpha1 (AP1) and pro-alpha2 (AP2) consensus sites and several CAAT regions. CALM3 also has clusters of specificity protein 1 (SP1) transcription factor. In human chromosome, the gene is localized on 19q13.32.
特異性
The antibody detects endogenous level of Calmodulin only when phosphorylated at threonine 79/serine 81.
免疫原
Peptide sequence around phosphorylation site of threonine79/serine81(K-D-T(p)-D-S(p)-E-E) derived from Human Calmodulin .
生化／生理作用
Calmodulin (CaM) encoded by Calmodulin 3 (CALM3) senses Ca2+ and binds to free signal-transducing protein that regulates Cav1.2 L-type calcium channel and deactivates Cav1.2 when CaM binds to free Ca2+. A sporadic mutation in CALM3 might be the cause for long QT syndrome, a disorder of ventricular myocardial repolarization, characterized by prolonged heart rate. CALM3 expression is higher in teratoma cells. CALM3 is a potential biomarker to dysregulate the melanoma cancer genes. Polymorphism in CALM3 is a potential modifier gene for familial hypertrophic cardiomyopathy.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer
Goto Y, et al.
Febs Letters, 588(10), 1973-1982 (2014)
Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALMS
Toutenhoofd SL, et al.
Cell Calcium, 23(5), 323-338 (1998)
Identification of melanoma biomarkers based on network modules by integrating the human signalling network with microarrays
Huang C, et al.
Journal of Cancer Research and Therapeutics, 10(7), 114-124 (2014)
A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy
Friedrich FW, et al.
European Heart Journal, 30(13), 1648-1655 (2009)
CALM3 mutation associated with long QT syndrome
Reed GJ, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 12(2), 419-422 (2015)
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