SAB4300554
Anti-NFKB1 (Ab-927) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-DKFZp686C01211 antibody produced in rabbit, Anti-EBP-1 antibody produced in rabbit, Anti-KBF1 antibody produced in rabbit, Anti-MGC54151 antibody produced in rabbit, Anti-nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antibody produced in rabbit
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About This Item
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~120 kDa
~50 kDa
物種活性
human, rat, mouse
濃度
1 mg/mL
技術
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(C-D-S-G-V)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NFKB1(4790)
一般說明
NFKB1(nuclear factor κB subunit 1) is a dimeric transcription factor. It belongs to the REL family. It is located on chromosome 4q24.
免疫原
Peptide sequence around aa. 925-929 (C-D-S-G-V ), according to the protein NFKB1.
生化／生理作用
NFKB1 (nuclear factor κB subunit 1) controls the maturation of NK (natural killer) cells and effector functions. It helps in the upregulation of intrauterine adhesion inflammatory factors, hence it plays a major role in inflammatory diseases.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells
Takada H, et al.
PLoS ONE, 12(3) (2017)
Yibo Gong et al.
BMC complementary medicine and therapies, 22(1), 224-224 (2022-08-27)
Oxidative stress can induce age-related diseases. Age-related retinal diseases, such as age-related macular degeneration (AMD), are difficult to cure owing to their complicated mechanisms. Although anti-neovascular therapeutics are used to treat wet AMD, vision cannot always be completely restored, and
NFKB1 regulates human NK cell maturation and effector functions
Lougaris V, et al.
Clinical Immunology (Orlando, Fla.), 175, 99-108 (2017)
Elevated NF-?B signaling in Asherman syndrome patients and animal models
Wang X, et al.
Oncotarget, 8(9), 15399-15406 (2017)
J Spring
FEBS letters, 400(1), 2-8 (1997-01-02)
For the growing fraction of human genes with identified functions there are often homologues known from invertebrates such as Drosophila. A survey of well established gene families from aldolases to zinc finger transcription factors reveals that usually a single invertebrate
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