SAB4300523
Anti-EIF2S1 (Ab-51) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-EIF-2 antibody produced in rabbit, Anti-EIF-2A antibody produced in rabbit, Anti-EIF-2alpha antibody produced in rabbit, Anti-EIF2 antibody produced in rabbit, Anti-eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa antibody produced in rabbit
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所有图片(3)
About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~38 kDa
物種活性
human, mouse, rat
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(E-L-S-R-R)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... EIF2S1(1965)
一般說明
The eukaryotic translation initiation factor 2 subunit α (EIF2S1) gene codes for a heterotrimeric GTPase which is localized to the cytoplasm. The EIF2S1 gene is mapped to human chromosome 14q23.3.
免疫原
Peptide sequence around aa. 49-53 (E-L-S-R-R), according to the protein EIF2S1.
生化／生理作用
EIF2S1 (eukaryotic translation initiation factor 2 subunit α) serves as an important enzyme in protein elongation during translation. EIF2S1 catalyses the translocation of peptidyl-tRNA from A site to P site in the ribosome. Phosphorylation by EF2 kinase, inactivates EIF2S1 followed by inhibition of protein synthesis. Upregulation of EIF2S1 gene is observed in malignant tumors, such as gastrointestinal cancer, lung adenocarcinoma, ovary cancer, soft-tissue sarcomas and hepatocellular carcinoma. The GTP-bound eIF2S1 protein is regarded as the active form and recruits initiator methionyl tRNA to 40S ribosomal subunit, one of the key step in translation initiation.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Identification of carboxypeptidase E and γ-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray.
He P, et al.
Human Pathology, 35(10), 1196-1209 (2004)
PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly.
Ilan L, et al.
Cell Research, 27(5), 688-688 (2017)
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Song Y, et al.
Oncotarget, 7(36), 58470-58470 (2016)
Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation.
Bogorad A M, et al.
Nucleic Acids Research, 45(20), 11962-11979 (2017)
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