SAB4300246

Anti-phospho-SHC1 (pTyr⁴²⁷) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-FLJ26504 antibody produced in rabbit, Anti-SHC (Src homology 2 domain containing) transforming protein 1 antibody produced in rabbit, Anti-SHC antibody produced in rabbit, Anti-SHCA antibody produced in rabbit
• MDL號碼: MFCD01634176
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~46 kDa; ~52 kDa
• 物種活性: human
• 濃度: 1 mg/mL
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 同型: IgG
• 免疫原序列: (P-S-YP-V-N
• NCBI登錄號: NP_001123512.1
• UniProt登錄號: P29353
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pTyr427)
• 基因資訊: human ... SHC1(6464)

说明

免疫原

Peptide sequence around phosphorylation site of tyrosine 427 (P-S-Y(p)-V-N, according to the protein SHC1.

特點和優勢

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標靶描述

Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable