SAB4300192

Anti-phospho-BRCA1 (pSer¹⁴²³) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit
• MDL號碼: MFCD01092286
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~220 kDa
• 物種活性: human
• 濃度: 1 mg/mL
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• 同型: IgG
• 免疫原序列: (H-G-SP-Q-P)
• NCBI登錄號: NP_009225.1
• UniProt登錄號: P38398
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pSer1423)
• 基因資訊: human ... BRCA1(672)

说明

免疫原

Peptide sequence around phosphorylation site of serine 1423 (H-G-S(p)-Q-P), according to the protein BRCA1.

特點和優勢

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標靶描述

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable