SAB4300056

Anti-phospho-PGR (pSer¹⁹⁰) antibody produced in rabbit

affinity isolated antibody

• 别名: Anti-NR3C3 antibody produced in rabbit, Anti-PR antibody produced in rabbit, Anti-progesterone receptor antibody produced in rabbit
• MDL號碼: MFCD00239723
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~99 kDa
• 物種活性: human
• 濃度: 1 mg/mL
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• 同型: IgG
• 免疫原序列: (G-L-SP-P-A)
• NCBI登錄號: NP_000917.3
• UniProt登錄號: P06401
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pSer190)
• 基因資訊: human ... PGR(5241)

说明

免疫原

Peptide sequence around phosphorylation site of serine 190 (G-L-S(p)-P-A), according to the protein PGR.

特點和優勢

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標靶描述

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable