生物源
rabbit
共軛
peroxidase conjugate
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
描述
Research area: Microbiome
形狀
lyophilized powder
物種活性
Pseudomonas aeruginosa
濃度
~4 mg/mL
技術
direct ELISA: 1:10,000-1:20,000 (is recommended using 1 μg/ml Pseudomonas Exotoxin A for coating.)
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
Pseudomonas aeruginosa PAO1 ... toxA(877850)
一般說明
Pseudomonas aeruginosa is a Gram negative bacterium that rarely cause diseases in humans but certain populations, such as cystic fibrosis (CF) or burn wounds patients, are prone to such infections.
Pseudomonas Exotoxin A (PE) is the most potent virulence factor secreted by P. aeruginosa, it is composed of three structural domains, N-terminal domain (I) responsible for the toxin binding to its host cell receptor, middle domain (II) has a role in toxin translocation across the membrane, and C-terminal domain (III) has ADP-ribosylation activity. PE is considered as a selective agent for the elimination of specific cell populations due to its toxin ADP-ribosylation activity resulting in irreversibly shut down of protein synthesis. To reduce the adverse effects of natural PE, Mutated PE was used in several attempts to develop recombinant toxin-antibody or cytokines fusion fragments for therapeutic application including cancer immunotherapy.
Pseudomonas Exotoxin A (PE) is the most potent virulence factor secreted by P. aeruginosa, it is composed of three structural domains, N-terminal domain (I) responsible for the toxin binding to its host cell receptor, middle domain (II) has a role in toxin translocation across the membrane, and C-terminal domain (III) has ADP-ribosylation activity. PE is considered as a selective agent for the elimination of specific cell populations due to its toxin ADP-ribosylation activity resulting in irreversibly shut down of protein synthesis. To reduce the adverse effects of natural PE, Mutated PE was used in several attempts to develop recombinant toxin-antibody or cytokines fusion fragments for therapeutic application including cancer immunotherapy.
免疫原
Purified Exotoxin A from Pseudomonas aeruginosa
應用
The antibody may be used in various immunochemical techniques including ELISA.
外觀
Supplied as a lyophilized powder.
其他說明
In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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