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Merck

SAB4200703

Sigma-Aldrich

Anti-Neurotensin/NTS antibody, Mouse monoclonal

clone NTS-11, purified from hybridoma cell culture

别名:

Anti- neurotensin, Anti-NMN125, Anti-NN, Anti-NT, Anti-NT/N

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.44

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

NTS-11, monoclonal

形狀

buffered aqueous solution

物種活性

rat, human

濃度

~1 mg/mL

技術

immunoblotting: 5-10 μg/mL using whole extract of SK-N-SH cells
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat brain sections

同型

IgG1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... NTS(4922)
rat ... Nts(299757)

一般說明

Anti-Neurotensin/NTS antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the NTS-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide. Neurotensin (also known as NTS or NT) is a 13 amino acid brain-gut peptide.

免疫原

Synthetic peptide from C-terminal region of human Neurotensin, conjugated to KLH

應用

Anti-Neurotensin/NTS antibody, Mouse monoclonal has been used in:
  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

生化/生理作用

Neurotensin (NTS) functions as a neurotransmitter/neuromodulator in the central nervous system (CNS) and as an endocrine agent in the gastrointestinal (GI) tract. Neurotensin is involved in a variety of physiological processes such as, stress and pain modulation, pathophysiology of drug addiction, schizophrenia, Parkinson disease, depression, locomotion and reward. In the brain, neurotensin modulates dopaminergic transmission in the nigrostriatal and mesocorticolimbic pathways as well as hormone secretion from the anterior pituitary.

外觀

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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The role of neurotensin as a novel biomarker in the endoscopic screening of high-risk population for developing colorectal neoplasia
Kontovounisios C, et al.
Updates in Surgery, 69(3), 397-397 (2017)
The role of neurotensin in central nervous system pathophysiology: What is the evidence?
St-Gelais F, et al.
Journal of Psychiatry & Neuroscience, 31(4), 229-229 (2006)
Collateral projections innervate the mammillary bodies and retrosplenial cortex: A new category of hippocampal cells
Kinnavane L, et al,.
eNeuro, 5(1) (2018)
Diverse Roles of Neurotensin Agonists in the Central Nervous System
Boules M, et al.
Frontiers in Endocrinology, 4 (2013)
Lisa Kinnavane et al.
eNeuro, 5(1) (2018-03-13)
To understand the hippocampus, it is necessary to understand the subiculum. Unlike other hippocampal subfields, the subiculum projects to almost all distal hippocampal targets, highlighting its critical importance for external networks. The present studies, in male rats and mice, reveal

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