生物来源
mouse
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
3F12, monoclonal
表单
buffered aqueous solution
分子量
antigen ~53 kDa
种属反应性
human, bovine, monkey
浓度
~1 mg/mL
技术
immunoblotting: 0.5-1 μg/mL using using whole extracts of HeLa cells.
immunofluorescence: 5-10 μg/mL using using HeLa cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TOM1L1(10040)
一般描述
The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23. The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, γ-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.
免疫原
immunized with a TOM1L1 fusion protein.
生化/生理作用
TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase). It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor. TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Béatrice Orsetti et al.
Cancer research, 64(18), 6453-6460 (2004-09-18)
Chromosome 17 is severely rearranged in breast cancer. Whereas the short arm undergoes frequent losses, the long arm harbors complex combinations of gains and losses. In this work we present a comprehensive study of quantitative anomalies at chromosome 17 by
Ning Sheng Liu et al.
The EMBO journal, 28(22), 3485-3499 (2009-10-03)
Although many proteins have been shown to participate in ligand-stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocytic machinery remains elusive. We show here that EGF stimulates transient tyrosine phosphorylation of Tom1L1
Yu Qi et al.
Anticancer research, 30(9), 3535-3539 (2010-10-15)
Src-family tyrosine kinases (SFKs) play critical roles in regulating cellular differentiation and proliferation. Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation. The aim of this study was to determine whether Srcasm
Ahmed Elmarghani et al.
Mediators of inflammation, 2009, 416298-416298 (2010-02-26)
TOM1L (target of Myb-1 Like) was identified as a binding partner for the full length and catalytically-active Lck in a yeast 2-hybrid screening assay. Here we show that in Jurkat T cells stimulated by CD3/CD28 coligation where the expression of
Audrey Sirvent et al.
Molecular & cellular proteomics : MCP, 11(12), 1937-1950 (2012-10-02)
The non-receptor tyrosine kinase SRC is frequently deregulated in human colorectal cancer (CRC), and SRC increased activity has been associated with poor clinical outcomes. In nude mice engrafted with human CRC cells, SRC over-expression favors tumor growth and is accompanied
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