SAB4200425
Anti-COG1 (N-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CDG2G, Anti-COG complex subunit 1, Anti-LDLB, Anti-component of oligomeric golgi complex 1, Anti-conserved oligomeric Golgi complex subunit 1, Anti-low density lipoprotein receptor defect B complementing
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所有图片(2)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~110 kDa
种属反应性
rat, mouse, human
浓度
~1.0 mg/mL
技术
western blot: 2.5-5.0 μg/mL using whole extracts of human HepG2 and rat PC12 cells.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COG1(9382)
mouse ... Cog1(16834)
rat ... Cog1(303652)
一般描述
The conserved oligomeric Golgi complex 1 (COG1) protein is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex contains eight subunits organized in two heterotrimeric groups, COG-2-COG3-COG4 and COG5-COG6-COG7, which are linked by the dimeric group formed by COG1 and COG8. The COG1 gene is located on the human chromosome at 17q25.1.
特异性
Anti-COG1 (N-terminal) recognizes human and rat COG1.
免疫原
peptide corresponding to the N-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and bovine COG1.
应用
Anti-COG1 (N-terminal) antibody produced in rabbit may be used in immunoblotting.
生化/生理作用
The conserved oligomeric Golgi complex 1 (COG1) protein is needed for normal Golgi function. It is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates. It also plays a role in the organization of the Golgi-localized complex. In humans, mutations in the COG subunit cause novel types of congenital disorders of glycosylation.
外形
solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Richard D Smith et al.
Carbohydrate research, 343(12), 2024-2031 (2008-03-21)
The Golgi apparatus is a central hub for both protein and lipid trafficking/sorting and is also a major site for glycosylation in the cell. This organelle employs a cohort of peripheral membrane proteins and protein complexes to keep its structural
Jin Hwan Do et al.
Molecules and cells, 24(1), 105-112 (2007-09-12)
Most neuroblastoma cells have chromosomal aberrations such as gains, losses, amplifications and deletions of DNA. Conventional approaches like fluorescence in situ hybridization (FISH) or metaphase comparative genomic hybridization (CGH) can detect chromosomal aberrations, but their resolution is low. In this
Rita Quental et al.
BMC evolutionary biology, 10, 212-212 (2010-07-17)
The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by
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