共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~15 kDa
物種活性
rat, human, mouse
技術
western blot: 1:1000-1:2000 using NIH3T3 or HeLa cell lysates
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
acetylation (Lys56)
基因資訊
human ... HIST3H3(8290)
一般說明
Histones are considered as the important constituents of chromatin. They are classified into core histones and linker histones. Histone H3 gene codes for a H3 protein sequence. This H3 gene is located on human chromosome 1 (1q42).
免疫原
synthetic peptide containing acetylated Lys56 of human histone H3, conjugated to KLH. The corresponding sequence is identical in many species including rat and mouse histone H3.
應用
Anti-acetyl-Histone H3 [Ac-Lys56] has been used in western blot analysis.
生化／生理作用
Core histones and linker histones are known possesses inter and intra-specific amino acid sequence variability. Histone modifications are thought to play an important role in cancer and disease. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. In human embryonic stem cells, histone H3 Lys56 acetylation is associated to the core transcriptional network.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Xie W, et al.
Molecular Cell, 33(4), 417-427 (2009)
A solitary human H3 histone gene on chromosome 1
Albig W, et al.
Human Genetics, 97(4), 486-491 (1996)
Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae
Azad GK, et al.
PLoS ONE, 8(3), e59003-e59003 (2013)
Histone Variants: Signaling or Structural Modules
Handbook of Cell Signaling, 2409-2425 (2010)
Shraddha Chauhan et al.
Environmental science and pollution research international, 31(20), 30149-30162 (2024-04-11)
Nanoparticles, particularly magnesium oxide nanoparticles (MgO-NPs), are increasingly utilized in various fields, yet their potential impact on cellular systems remains a topic of concern. This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae
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