生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~40 kDa
物種活性
human
包裝
antibody small pack of 25 μL
濃度
~1.0 mg/mL
技術
immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXD9
indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXD9
western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human HOXD9
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HOXD9(3235)
mouse ... Hoxd9(15438)
rat ... Hoxd9(688999)
一般說明
There are 39 homeobox (HOX) genes in vertebrates. They are divided into four clusters (HOXA−HOXD), located on different chromosomes (7p15, 17q21.2, 12q13 and 2q31). Each cluster contains 9−11 member genes encoding relatively small gene products containing a highly conserved 60-amino-acid region (the homeobox), with DNA-binding activity that contributes to their activity as transcription factors. The HOX genes are evolutionarily conserved.
應用
Anti-HOXD9 (Internal Region) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
生化/生理作用
Homeobox (HOX) transcription factors control important development pathways involved embryo morphogenesis. HOX genes mainly participate in the formation of the body plan during embryonic development. Altered homeobox gene function or expression is implicated in the development of cancers such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin, and brain. HOXD9 is involved in patterning of forelimb, axial skeleton and embryonic segmentation. It might promote cell migration, invasion and metastasis in hepatocellular carcinoma. HOXD9 was shown to be involved in the early stages of normal joint development and also in the pathologic process of arthritis.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma
Lv X, et al.
Journal of Experimental & Clinical Cancer Research, 34(1), 133-133 (2015)
Role of HOX genes in stem cell differentiation and Cancer
Bhatlekar S, et al.
Stem Cells International, 2018(1), 107-113 (2018)
Histone acetylation regulates the expression of HoxD9 transcription factor in endothelial progenitor cells
Iordache F, et al.
Romanian Journal of Morphology and Embryology, 56(1), 107-113 (2015)
Expression of murine HOXD9 during embryonic joint patterning and in human T lymphotropic virus type I tax transgenic mice with arthropathy resembling rheumatoid arthritis.
Khoa ND, et al.
Arthritis and Rheumatism, 42(4), 686-696 (1999)
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