SAB4100235

Monoclonal Anti-SAMHD1 antibody produced in mouse

clone SAMHD1-A200, culture supernatant

• 别名: AntiAGS5, AntiDCIP, AntiHD domain containing 1, AntiHDDC1, AntiMOP-5, AntiOTTHUMP00000030889, AntiSAM domain and HD domain 1, AntiSAM domain- and HD domain-containing protein 1, AntiSBBI88
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: mouse
• 偶联物: unconjugated
• 抗体形式: culture supernatant
• 抗体产品类型: primary antibodies
• 克隆: SAMHD1-A200, monoclonal
• 表单: aqueous solution
• 分子量: antigen predicted mol wt 72 kDa
• 种属反应性: human
• 技术: western blot: suitable
• 同位素/亚型: IgG1
• UniProt登记号: Q9Y3Z3
• 运输: dry ice
• 储存温度: −20°C
• 基因信息: human ... SAMHD1(25939)

说明

一般描述

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is a deoxynucleoside triphosphate triphosphohydrolase with sterile alpha motif (SAM) and a dGTP-regulated dNTP hydrolase domain (HD). SAMHD1 gene is mapped to human chromosome 20q11.23.

免疫原

SAMHD1 purified recombinant protein

生化/生理作用

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is a key enzyme, which controls the levels of dinucleotide triphosphates. It also acts as an immune response factor cum restriction factor for many virues including the human immunodeficiency virus (HIV) hepatitis B virus (HBV) and herpes simplex virus 1 (HSV-1). SAMHD1 interferon-stimulated gene (ISG) also regulates the human cytomegalovirus and papillomavirus life cycles. Mutation in the SAMHD1 leads to imbalance in dinucleotide levels and is implicated in Aicardi‐Goutières syndrome (AGS) Mutation in SAMHD1 along with Three Prime Repair Exonuclease 1 (TREX1) and Stimulator of interferon genes (STING) genes is also correlated to familial chilblain lupus (FCL).

外形

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable