SAB3501188

Anti-DC-SIGN antibody produced in rabbit

affinity isolated antibody

• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: liquid
• 种属反应性: human
• 浓度: 1 mg/mL
• 技术: immunohistochemistry: suitable; western blot: suitable
• 同位素/亚型: IgG
• UniProt登记号: Q9NNX6
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... CD209(30835)

说明

一般描述

DC-SIGN Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

免疫原

DC-SIGN antibody was raised against a synthetic peptide corresponding to 17 amino acids near the center of human DC-SIGN.The immunogen is located within amino acids 250 - 300 of DC-SIGN.

应用

DC-SIGN antibody can be used for detection of DC-SIGN by Western blot at 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

外形

Supplied in PBS containing 0.02% sodium azide.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: nwg
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable