推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
mouse, human
技術
indirect ELISA: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ANO1(55107)
一般說明
Transmembrane member 16A (TMEM16A) or Anoctamin1 (Ano1) is a calcium-activated chloride channel. It is expressed in the interstitial cells of Cajal (ICC) in the gastrointestinal tract. The gene encoding this protein is localized on human chromosome 11q13.3.
免疫原
TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.
生化／生理作用
Transmembrane member 16A (TMEM16A) or Ano1 is crucial for normal electrical slow waves and for the proliferation of interstitial cells of Cajal (ICC). The protein has a role in smooth muscle contraction, salivary secretion and cardiac and neuronal excitability. TMEM16A has been associated with head and neck squamous cell carcinoma and breast cancer.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
聯結
The action of this antibody can be blocked using blocking peptide SBP3500318.
外觀
Supplied in PBS with 0.02% sodium azide.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.
Strege PR
American Journal of Physiology: Gastrointestinal and Liver Physiology (2017)
GDD1 Is Identical to TMEM16E, a Member of the TMEM16 Family
Masuko K
American Journal of Human Genetics (2004)
TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.
Kulkarni S
Genes Chromosomes Cancer (2017)
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