生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, human, mouse
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... WDR74(54663)
一般描述
WD repeat domain 74 (WDR74), also known as NOP seven-associated protein 1 (NSA1), is encoded by the gene mapped to human chromosome 11q12.3. The encoded protein is mainly localized in the nucleus and it contains six WD40 repeats.
免疫原
NSA1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human NSA1.
生化/生理作用
WD repeat domain 74 (WDR74) along with the nucleolar AAA-ATPase NVL2, plays a vital role in an early cleavage of the pre-rRNA processing pathway. It is also implicated in various biological processes, including cell cycle control and apoptosis. In mouse, this protein plays an essential role in RNA transcription, processing and/or stability during preimplantation development.
特点和优势
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联系
The action of this antibody can be blocked using blocking peptide SBP3500152.
外形
Supplied in PBS with 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer
Mansilla F, et al.
Scholarly Research Exchange (2009)
Genome-wide analysis of non-coding regulatory mutations in cancer
Weinhold N, et al.
Nature Genetics, 46(11), 1160-1160 (2014)
Wdr74 Is Required for Blastocyst Formation in the Mouse
Maserati M, et al.
PLoS ONE, 6(7), e22516-e22516 (2011)
WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2.
Hiraishi N, et al.
Biochemical and Biophysical Research Communications, 495(1), 116-123 (2018)
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