SAB3500113

Anti-FRMPD1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 别名: Anti-FERM and PDZ domain-containing 1, Anti-FRMD2
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 种属反应性: human
• 技术: immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI登记号: NP_055722
• UniProt登记号: Q5SYB0
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... FRMPD1(22844)

说明

免疫原

FRMPD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human FRMPD1.

特点和优势

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目标描述

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.

联系

The action of this antibody can be blocked using blocking peptide SBP3500113.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable