SAB3500027

Anti-ZBED1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 别名: Anti-ALTE, Anti-DREF, Anti-TRAMP, Anti-Zinc finger BED-type domain containing 1, Anti-hDREF
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 种属反应性: human, mouse
• 技术: indirect ELISA: suitable; western blot: suitable
• NCBI登记号: AAH15030
• UniProt登记号: O96006
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... ZBED1(9189)

说明

免疫原

ZBED1 antibody was raised against a 15 amino acid peptide from near the center of human ZBED1.

特点和优势

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目标描述

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding. This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.

联系

The action of this antibody can be blocked using blocking peptide SBP3500027.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable