SAB1409989

Monoclonal Anti-PTTG1 antibody produced in mouse

clone 1G10, purified immunoglobulin, buffered aqueous solution

• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: mouse
• 质量水平: 100
• 偶联物: unconjugated
• 抗体形式: purified immunoglobulin
• 抗体产品类型: primary antibodies
• 克隆: 1G10, monoclonal
• 表单: buffered aqueous solution
• 种属反应性: human
• 技术: immunofluorescence: suitable; indirect ELISA: suitable
• 同位素/亚型: IgG2bκ
• NCBI登记号: NM_004219
• UniProt登记号: O95997
• 运输: dry ice
• 储存温度: −20°C
• 靶向翻译后修饰: unmodified
• 基因信息: human ... PTTG1(9232)

说明

一般描述

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. (provided by RefSeq)

免疫原

PTTG1 (NP_004210, 93 a.a. ~ 113 a.a) synthetic peptide.

Sequence
MTEKTVKAKSSVPASDDAYPE

外形

Solution in phosphate buffered saline, pH 7.4

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable