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Merck

S8071

Sigma-Aldrich

丹酚 A

≥98% (HPLC), solid

别名:

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(乙酰氧基)-2-(3-呋喃基)十二氢-6a,10b-二甲基-4,10-二氧代-2H-萘[2,1 -c]吡喃-7-羧酸甲酯

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About This Item

经验公式(希尔记法):
C23H28O8
CAS号:
分子量:
432.46
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

儲存條件

protect from light

顏色

white

溶解度

DMSO: ≥10 mg/mL
ethanol: ~3 mg/mL

儲存溫度

−20°C

SMILES 字串

[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

InChI 密鑰

OBSYBRPAKCASQB-AGQYDFLVSA-N

基因資訊

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應用

给予大鼠Salvinorin A来研究其对乳酸刺激的拉伸的影响。1

生化/生理作用

Salvinorin A是一种有效的无氮κ阿片类选择性受体激动剂。Salvinorin A分离自墨西哥鼠尾草。Salvinorin A在天然(Ki = 4.3 nm)和克隆的(Ki = 16 nm)κ -阿片受体上均表现出高亲和力。初步研究表明,Salvanorin A在精神药物中具有独特的化学性质并不与任何已知受体结合。

特點和優勢

《受体分类和信号转导》手册的 阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

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John Stogner et al.
The International journal on drug policy, 23(6), 512-521 (2012-04-17)
A plant with dissociative and psychoactive properties began to attract the attention of the media and United States policymakers following a well-publicized suicide in 2006 and reports that the plant served as a 'legal high' and substitute for cannabis. As
Thomas E Prisinzano
Journal of medicinal chemistry, 56(9), 3435-3443 (2013-04-04)
The neoclerodane diterpene salvinorin A is the major active component of the hallucinogenic mint plant Salvia divinorum Epling and Játiva (Lamiaceae). Since the finding that salvinorin A exerts its potent psychotropic actions through the activation of opioid receptors, the site
Francesca Guida et al.
Molecular pain, 8, 60-60 (2012-08-24)
Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and the mode
Justyna Piekielna et al.
Postepy biochemii, 58(4), 485-491 (2012-01-01)
Salvinorin A (SA) is the main active ingredient of Salvia divinorum, a naturally occurring hallucinogen plant from Mexico. Traditionally, herbal preparations obtained from Salvia were used by the Mazatec Indians for their divination rites and the treatment of gastrointestinal disorders.
Diansan Su et al.
Anesthesia and analgesia, 114(1), 200-204 (2011-11-15)
Cerebral hypoxia/ischemia during infant congenital heart surgery is not uncommon and may induce devastating neurologic disabilities persistent over the lifespan. Hypoxia/ischemia-induced cerebrovascular dysfunction is thought to be an important contributor to neurological damage. No pharmacological agents have been found to

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