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物種活性
human
包裝
kit of 96 wells (12 strips x 8 wells)
技術
ELISA: suitable
capture ELISA: suitable
輸入
sample type serum
sample type cell culture supernatant(s)
sample type plasma
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 100 pg/mL
standard curve range: 0.124-30 ng/mL
檢測方法
colorimetric
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... IL1RN(3557)
一般說明
The Human IL-1ra ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human IL-1ra in serum, plasma, cell culture supernatants and urine.
免疫原
Recombinant Human IL-1 Receptor Antagonist
應用
请参考Protocol了解详情。
生化／生理作用
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively binding to their type I and type II receptors. IL-1RA plays a vital role in inhibition of acute pro-inflammatory response and forbidding chronic inflammation from damaging healthy tissues. Abnormal expression of IL-1RA leads to development of inflammatory or autoimmune related diseases. Allelic polymorphism of IL-1RA leads to inflammatory bowel disease (IBD). Therapeutically, IL-1RA may help in the treatment of sepsis, rheumatoid arthritis, asthma. Overexpression of IL-1RA is observed in serum of psoriatic arthritis (PsA) patients.
其他說明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
试剂盒组分也可单独购买
产品编号
说明
化学品安全说明书
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8A - Combustible corrosive hazardous materials
Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium.
Sousa AR
American Journal of Respiratory and Critical Care Medicine, 154(4 Pt 1), 1061-1066 (1996)
Serum levels of IL-10, IL-6, IL-1ra, and sIL-2R in patients with psoriatic arthritis.
Elkayam O
Rheumatology International, 19(3), 101-105 (2000)
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.
Bresnihan B
Arthritis and Rheumatism, 41(12), 2196-2204 (1998)
A novel association between IL1-Ra (receptor antagonist) gene polymorphism and T1DM in Al-Madina Al-Mounawra.
Ali RA
European Review for Medical and Pharmacological Sciences, 19(19), 3701-3708 (2015)
Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock.
Arnalich F
The Journal of Infectious Diseases, 180(3), 908-911 (1999)
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