R4282

RF9 trifluoroacetate salt

≥97% (HPLC)

• 别名: 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt
• 经验公式（希尔记法）: C₂₆H₃₈N₆O₃ · xC₂HF₃O₂
• CAS号: 876310-60-0
• 分子量: 482.62 (free base basis)
• UNSPSC代码: 12352200
• PubChem化学物质编号: 329824030
• NACRES: NA.77

属性

• 方案: ≥97% (HPLC)
• 溶解性: H₂O: 20 mg/mL
• 储存温度: −20°C
• SMILES字符串: OC(=O)C(F)(F)F.NC(=N)NCCC[C@H](NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C26H38N6O3.C2HF3O2/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26;3-2(4,5)1(6)7/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30);(H,6,7)/t17-,18+,19-,20-,21-,26-;/m0./s1
• InChI key: GPVFYPYIOXHDCU-CFIUKZCSSA-N

说明

生化/生理作用

RF9 is a neuropeptide FF receptor antagonist.

RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.

安全信息

• 储存分类代码: 13 - Non Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)