R3405

RP-107

≥98% (HPLC), solid

• 别名: 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
• 经验公式（希尔记法）: C₁₆H₁₇N₃O
• CAS号: 496864-15-4
• 分子量: 267.33
• MDL號碼: MFCD04973541
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329824024

属性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: desiccated
• 溶解度: DMSO: >10 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
• InChI: 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• InChI 密鑰: PRIGRJPRGZCFAS-UHFFFAOYSA-N

说明

生化／生理作用

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC₅₀ = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

特點和優勢

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves