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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
room temp
SMILES 字串
NC(C1=C(OC)C=C2C(C=CN=C2OC[C@@H]3[C@H](CC)[C@H](F)C(N3)=O)=C1)=O
InChI
1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1
InChI 密鑰
JKDGKIBAOAFRPJ-ZBINZKHDSA-N
生化／生理作用
PF06650833已被研究用于治疗Waldenstrom巨球蛋白血症，其表现为可产生IgM（免疫球蛋白M）的淋巴浆细胞的过量产生。
PF06650833是白介素-1受体相关激酶4（IRAK4）的一种抑制剂。IRAK4激酶在先天免疫中具有重要作用，可参与到来自Toll样受体和einterleukin-1受体家族成员的信号转导启动。IRAK4激酶是治疗与炎症失调相关的各种疾病，如类风湿关节炎、骨关节炎、炎症性肠病和系统性红斑狼疮的一种重要靶标。PF06650833已被研究用于治疗狼疮。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sadiq Umar et al.
Cellular & molecular immunology (2020-05-18)
Flares of joint inflammation and resistance to currently available biologic therapeutics in rheumatoid arthritis (RA) patients could reflect activation of innate immune mechanisms. Herein, we show that a TLR7 GU-rich endogenous ligand, miR-Let7b, potentiates synovitis by amplifying RA monocyte and
Rafael Deliz-Aguirre et al.
The Journal of cell biology, 220(7) (2021-05-07)
A recurring feature of innate immune receptor signaling is the self-assembly of signaling proteins into oligomeric complexes. The Myddosome is an oligomeric complex that is required to transmit inflammatory signals from TLR/IL1Rs and consists of MyD88 and IRAK family kinases.
Kinase inhibitors in clinical practice: An expanding world.
Pandey R and Reuben K
The Journal of Allergy and Clinical Immunology, 141(2), 522-524 (2018)
Future therapeutic options for patients with Waldenstrom macroglobulinemia.
Castillo J J, et al.
Best Practice & Research. Clinical Haematology, 29(2), 206-215 (2016)
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