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Merck
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文件

PZ0234

Sigma-Aldrich

PF-543 盐酸盐

≥98% (HPLC)

别名:

PF-05144543 盐酸盐, （2R）-1-[[[4-[[3-甲基-5-[（苯磺酰基）甲基]苯氧基]甲基]苯基]甲基] -2-吡咯烷甲醇 盐酸盐, （R）-（1-（4-（（3-甲基-5-（苯磺酰基甲基）苯氧基）甲基）苄基）吡咯烷-2-基）甲醇 盐酸盐

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About This Item

经验公式（希尔记法）:
C27H31NO4S · HCl
CAS号:
1415562-82-1
分子量:
502.07
MDL號碼:
MFCD28411614
分類程式碼代碼:
12352200
PubChem物質ID:
329823785
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to light brown

溶解度

H2O: 20 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

[H]Cl.CC1=CC(OCC2=CC=C(CN3[C@@H](CO)CCC3)C=C2)=CC(CS(C4=CC=CC=C4)(=O)=O)=C1

InChI

1S/C27H31NO4S.ClH/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29;/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3;1H/t25-;/m1./s1

InChI 密鑰

WNKWAZFYPZMDGJ-VQIWEWKSSA-N

生化／生理作用

PF-543可刺激微管相关蛋白轻链3（LC3）的颗粒积累。它还会诱导LC3-I向LC3-II的转化，并受到自噬抑制剂，渥曼青霉素、3-甲基腺嘌呤（3-MA）和巴氟霉素A1的抑制。在人的头颈部鳞状细胞癌（SCC）细胞中，PF-543盐酸盐可促进坏死、凋亡和自噬。
PF-543盐酸盐是一种全新的、细胞可渗透的、有效的、选择性的鞘氨醇激酶-1（SphK1）抑制剂。 PF-543可抑制SphK1，其Ki值为3.6 nM，其与鞘氨醇具有竞争性，对SphK1的选择性是SphK2同种型的100倍以上。PF-543可将内源性S1P的水平降低10倍，并与鞘氨醇的水平成比例地增加。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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