PZ0188

PF-3644022 水合物

≥98% (HPLC)

• 别名: (10R)-9,10,11,12-tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-f]quinolin-8-one hydrate
• 经验公式（希尔记法）: C₂₁H₁₈N₄OS · xH₂O
• 分子量: 374.46 (anhydrous basis)
• MDL號碼: MFCD21363374
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329823762
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: yellow to orange
• 溶解度: DMSO: ≥15 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O.C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c5ccc(C)nc5)C(=O)N1
• InChI: 1S/C21H18N4OS.H2O/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19;/h3-8,10,12,23H,9H2,1-2H3,(H,24,26);1H2/t12-;/m1./s1
• InChI 密鑰: WHVUIWUUCVXAGR-UTONKHPSSA-N

说明

應用

PF-3644022 hydrate has been used for the inhibition of mitogen-activated protein kinase 2 (MK2) in human osteosarcoma cells (U2OS) and in colorectal carcinoma cells (CT26).

生化／生理作用

PF-3644022 is a potent inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2; Ki = 3 nM). PF-3644022 inhibits TNFa and IL-6 production in LPS-stimulated human whole blood (IC₅₀ = 1.6 and 10.3 μM, respectively) and blocks TNFα production and paw swelling in a streptococcal cell wall-induced arthritis in rats.

特點和優勢

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

其他說明

PF3644022 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF3644022 probe summary on the Chemical Probes Portal website.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H319
• 防範說明: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable