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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
predicted mol wt 46 kDa
物種活性
mouse, human, rat
技術
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Casp12(12364)
一般說明
Caspase-12 (CASP12) is an immunomodulatory factor, that is present in the cytoplasmic side of the ER (endoplasmic reticulum). It is upregulated highly in muscle, liver and kidney.
免疫原
a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.
生化／生理作用
Caspase-12 (CASP12) plays an important role in endoplasmic reticulum (ER)-related apoptosis. It moderates hepatocyte apoptosis prompted by carbon tetrachloride. Lack of caspase-12 (CASP12) increases cytokine responses.
聯結
The action of this antibody can be blocked using blocking peptide SBP3197.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Caspase-12 deficiency enhances cytokine responses but does not protect against lethal Plasmodium yoelii 17XL infection
Miu J, et al.
Parasite Immunology, 32(11-12), 773-778 (2010)
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
Liu H, et al.
World Journal of Gastroenterology, 20(48), 18189-18198 (2014)
The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro
Liu LQ, et al.
Alcoholism, Clinical and Experimental Research, 38(3), 683-693 (2014)
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance
Skeldon AM, et al.
Journal of Immunology, 196(1), 437-447 (2016)
Juan Carlos Gómora-García et al.
Cell death discovery, 7(1), 131-131 (2021-06-05)
Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the unfolded protein response (UPR), which can act as a homeostatic response
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