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Merck

P1742

Sigma-Aldrich

前白蛋白 来源于人类血浆

lyophilized powder

别名:

甲状腺素结合前白蛋白, 甲状腺素运载蛋白

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About This Item

CAS号:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.25

生物源

human plasma

品質等級

化驗

≥95% (SDS-PAGE)

形狀

lyophilized powder

技術

immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable

溶解度

H2O: soluble 1 mg/mL

&epsilon ;(消光係數)

13.5 at 280 nm at 1%

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... TTR(7276)

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一般說明

人前白蛋白是18号染色体的产物。它是一种血清蛋白,主要在肝脏中合成。 它是一种四聚体蛋白,分子量为55 kDa。人前白蛋白由非共价结合的四个相同的单体(127个氨基酸残基)组成,排列成对称的四面体。

應用

人前白蛋白用于研究肺癌血清中甲状腺素运载蛋白表达的下调。
前白蛋白(来自人血浆)已用作免疫沉淀的阳性对照作为火箭免疫电泳法定量分析脑脊液的参考标准品。

生化/生理作用

人前白蛋白可在类癌瘤中观察到。
前白蛋白水平是营养不良的指示剂,而且可能受到炎症反应调节。在慢性肾衰竭患者的透析期间,它被视为蛋白质能量营养不良(PEM)的潜在标志物。低水平的前蛋白会导致心脏衰竭(HF)风险提高。

包裝

包装规格基于蛋白含量

外觀

含有磷酸钠和NaCl的冻干粉

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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K Nelson et al.
International journal of cancer, 15(5), 806-814 (1975-05-15)
Spleen cells from BALB/c mice which either bore syngeneic sarcomas or were normal controls were cultured in vitro. The culture supernatants of spleen cells from tumor-bearing mice inhibited (blocked) specific cell-mediated cytotoxicity to the tumor borne by the spleen donor.
Prealbumin is as important as albumin in the nutritional assessment of hemodialysis patients
Chertow GM, et al.
Kidney International, 58(6), 2512-2517 (2000)
Takashi Ito et al.
Internal medicine (Tokyo, Japan), 45(20), 1173-1175 (2006-11-16)
Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a
Haruki Koike et al.
Journal of neurology, 255(10), 1526-1533 (2008-09-30)
Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed. To examine the electrophysiological features of late-onset FAP TTR Met30 unrelated to endemic
J P Hegmann
Behavior genetics, 9(3), 165-175 (1979-05-01)
Behavioral and physiological scores from 697 mice sampled from lines at various times during their response to bidirectional selection for divergent caudal nerve conduction velocity suggest broad-reaching behavioral effects of the gene differences among lines. Sciatic nerve conduction velocity differences

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