所有图片(1)
About This Item
经验公式（希尔记法）:
C24H32Cl2N2O3 · 2HCl
CAS号:
分子量:
540.35
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.77
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形狀
solid
藥物控制
regulated under CDSA - not available from Sigma-Aldrich Canada
顏色
white
溶解度
H2O: soluble (use aqueous solutions immediately.)
ethanol: soluble (is stable for ca. 1 month in the freezer.)
polar organic solvents: soluble
儲存溫度
−20°C
SMILES 字串
Cl.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)[C@@H](CC[C@@]35O)N(CCCl)CCCl)CC6CC6
InChI
1S/C24H32Cl2N2O3.2ClH/c25-8-11-27(12-9-26)17-5-6-24(30)19-13-16-3-4-18(29)21-20(16)23(24,22(17)31-21)7-10-28(19)14-15-1-2-15;;/h3-4,15,17,19,22,29-30H,1-2,5-14H2;2*1H/t17-,19-,22+,23+,24-;;/m1../s1
InChI 密鑰
JJZDLJGFHABVOM-QNWHWJQFSA-N
生化／生理作用
Irreversible μ, δ and κ opioid receptor antagonist.
特點和優勢
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
Hygroscopic, photosensitive.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
H W Suh et al.
Neuropeptides, 27(2), 143-149 (1994-08-01)
Chlornaltrexamine (beta-CNA, 0.5 micrograms) alone or beta-CNA plus either mu-agonist, D-Ala2-NMePhe4-Gly-ol-enkephalin (DAMGO, 500 ng) or delta-agonist, D-Pen2-D-Pen5-enkephalin (DPDPE, 10 micrograms) was injected intrathecally (i.t.) to protect mu- or delta-opioid receptors, respectively, for 24 h in male ICR mice. The antinociception
I F James et al.
Molecular pharmacology, 25(3), 337-342 (1984-05-01)
We report a method for measuring and expressing the binding selectivity of ligands for mu, delta, and kappa opioid binding sites. We used radioligands that are partially selective for these sites in combination with membrane preparations enriched in each site.
R M Quock et al.
Brain research, 549(1), 162-164 (1991-05-17)
Nitrous oxide antinociception in the abdominal constriction test was significantly reduced in mice pretreated intracerebroventricularly (i.c.v.) with beta-chlornaltrexamine (beta-CNA). However, this antagonism was reversed when the beta-CNA was co-administered i.c.v. with the kappa-opioid ligand U-50,488H but not the mu-opioid ligand
J R Nicholson et al.
Canadian journal of physiology and pharmacology, 76(3), 304-313 (1998-07-23)
We have exploited the availability of the "orphan" opioid receptor (referred to here as ORL1) in its "natural state" to investigate the effect of nociceptin (orphanin FQ), the endogenous agonist for the ORL1 receptor in the brain, vas deferens, and
T A Macey et al.
Neuroscience, 168(2), 543-550 (2010-04-17)
Microinjection of opioids into the ventrolateral periaqueductal gray (vlPAG) produces antinociception in part by binding to mu-opioid receptors (MOPrs). Although both high and low efficacy agonists produce antinociception, low efficacy agonists such as morphine produce limited MOPr internalization suggesting that
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