N6414

NN-DNJ

≥98% (HPLC)

• 经验公式（希尔记法）: C₁₅H₃₁NO₄
• CAS号: 81117-35-3
• 分子量: 289.41
• MDL號碼: MFCD00905846
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329818665
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 溶解度: DMSO: >10 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
• InChI: 1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
• InChI 密鑰: FTSCEGKYKXESFF-LXTVHRRPSA-N

说明

生化／生理作用

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves