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Merck
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文件

N5764

Sigma-Aldrich

乳酸链球菌肽 来源于乳酸乳球菌

potency: ≥900 IU/mg

别名:

Nisin A

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About This Item

经验公式（希尔记法）:
C143H230N42O37S7
CAS号:
1414-45-5
分子量:
3354.07
MDL號碼:
MFCD00131724
分類程式碼代碼:
51102829
PubChem物質ID:
24897751
NACRES:
NA.85

形狀

powder

品質等級

200

效力

≥900 IU/mg

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

[H]N[C@@H]([C@@H](C)CC)C(=O)N\C(=C\C)C(=O)N[C@H]1CSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@H]2[C@H](C)SC[C@H](NC(=O)CNC(=O)[C@@H]3CCCN3C2=O)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]4[C@@H](C)SC[C@H](NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC4=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]5[C@H](C)SC[C@@H]6NC(=O)[C@@H](NC(=O)[C@H](C)NC5=O)[C@H](C)SC[C@H](NC(=O)[C@H](Cc7cnc[nH]7)NC6=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc8cnc[nH]8)C(=O)N[C@@H](C(C)C)C(=O)NC(=C)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C143H230N42O37S7/c1-24-69(11)105(148)135(213)162-82(27-4)118(196)174-94-58-225-59-95(175-123(201)89(48-67(7)8)169-115(193)74(16)158-138(216)107(70(12)25-2)180-132(94)210)133(211)184-112-79(21)229-61-96(160-104(190)56-152-134(212)100-38-34-44-185(100)142(112)220)128(206)164-84(36-29-32-42-145)120(198)182-109-76(18)226-60-97(161-103(189)55-151-117(195)85(39-45-223-22)165-122(200)88(47-66(5)6)168-113(191)72(14)156-102(188)54-153-136(109)214)129(207)171-92(51-101(147)187)125(203)166-86(40-46-224-23)119(197)163-83(35-28-31-41-144)121(199)183-110-77(19)228-63-99-130(208)170-90(49-80-52-149-64-154-80)124(202)176-98(62-227-78(20)111(141(219)177-99)181-116(194)75(17)159-140(110)218)131(209)173-93(57-186)127(205)179-108(71(13)26-3)139(217)172-91(50-81-53-150-65-155-81)126(204)178-106(68(9)10)137(215)157-73(15)114(192)167-87(143(221)222)37-30-33-43-146/h27,52-53,64-72,75-79,83-100,105-112,186H,15-16,24-26,28-51,54-63,144-146,148H2,1-14,17-23H3,(H2,147,187)(H,149,154)(H,150,155)(H,151,195)(H,152,212)(H,153,214)(H,156,188)(H,157,215)(H,158,216)(H,159,218)(H,160,190)(H,161,189)(H,162,213)(H,163,197)(H,164,206)(H,165,200)(H,166,203)(H,167,192)(H,168,191)(H,169,193)(H,170,208)(H,171,207)(H,172,217)(H,173,209)(H,174,196)(H,175,201)(H,176,202)(H,177,219)(H,178,204)(H,179,205)(H,180,210)(H,181,194)(H,182,198)(H,183,199)(H,184,211)(H,221,222)/b82-27+/t69-,70-,71-,72-,75-,76?,77?,78?,79?,83-,84+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,105-,106-,107-,108-,109+,110-,111-,112-/m0/s1

InChI 密鑰

NVNLLIYOARQCIX-ILAIHEEGSA-N

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相关类别

一般說明

化学结构：肽

應用

乳链菌肽是由乳酸乳球菌产生。它通常用作食品防腐剂。它也被用作细胞培养物中的选择性试剂，用于分离革兰氏阴性细菌、酵母和霉菌。乳链菌肽已在生物测定中用于研究翻译后修饰。
可用于在脂质II介导的细胞膜上形成目标孔。 可用于研究乳链菌肽-脂质II孔复合物的组装和稳定性。

生化／生理作用

乳链菌肽可结合细菌的细胞壁前体脂质成分并破坏细胞壁产生。乳链菌肽可改变细胞膜，并导致细胞质成分的泄漏和质子动力的破坏。
乳酸链球菌素(Nisin)是具有杀菌作用的抗生素。 它可与细菌脂多糖的脂质A部分结合，并可导致高粱离体根来源皮层细胞的细胞膜穿孔。

作用机制：结合并干扰细胞质膜的通透性。
抗菌谱：革兰氏阴性和革兰氏阳性细菌（需要螯合剂，例如EDTA）。

包裝

包装尺寸基于总固体重量

其他說明

保存于密闭容器内，置于干燥通风处。置于干燥处保存。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Olli Koponen et al.
Microbiology (Reading, England), 148(Pt 11), 3561-3568 (2002-11-13)
Nisin produced by Lactococcus lactis subsp. lactis is a 34-residue antibacterial polypeptide and belongs to a group of post-translationally modified peptides, lantibiotics, with dehydrated residues and cyclic amino acids, lanthionines. These modifications are supposed to be made by enzymes encoded
Qi Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(45), 18361-18366 (2012-10-17)
Lanthionine-containing peptides (lanthipeptides) are a family of ribosomally synthesized and posttranslationally modified peptides containing (methyl)lanthionine residues. Here we present a phylogenomic study of the four currently known classes of lanthipeptide synthetases (LanB and LanC for class I, LanM for class
Des Field et al.
PloS one, 7(10), e46884-e46884 (2012-10-12)
Nisin is a bacteriocin widely utilized in more than 50 countries as a safe and natural antibacterial food preservative. It is the most extensively studied bacteriocin, having undergone decades of bioengineering with a view to improving function and physicochemical properties.
Michaela Wenzel et al.
Antimicrobial agents and chemotherapy, 56(11), 5749-5757 (2012-08-29)
Mersacidin, gallidermin, and nisin are lantibiotics, antimicrobial peptides containing lanthionine. They show potent antibacterial activity. All three interfere with cell wall biosynthesis by binding lipid II, but they display different levels of interaction with the cytoplasmic membrane. On one end
Paul D Cotter
Bioengineered, 3(6), 313-319 (2012-08-28)
While the bacteriocin Nisin has been employed by the food industry for 60 y, it remains the only bacteriocin to be extensively employed as a food preservative. This is despite the fact that the activity of Nisin against several food
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Antimicrobial Peptides

Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.

抗菌肽

由于细菌耐药性和新出现的传染病成为人类的潜在威胁，核糖体合成的抗菌肽已成为抗生素研究的一个有前途的重点领域。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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