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N4786

NPS 2390

Name: NPS 2390
Brand: SIGMA

≥99% (HPLC), solid

别名:

Quinoxaline-2-carboxylic acid adamantan-1-ylamide

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About This Item

经验公式（希尔记法）:

C₁₉H₂₁ON₃

CAS号:

226878-01-9

分子量:

307.39

MDL编号:

MFCD05865239

UNSPSC代码:

12352200

PubChem化学物质编号:

329818648

描述

Caution-Not Yet Fully Tested-For Research Use Only-Not For Human Use.

方案

≥99% (HPLC)

表单

solid

颜色

white

溶解性

DMSO: soluble ~5 mg/mL
H₂O: insoluble

储存温度

2-8°C

SMILES字符串

O=C(NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2)c4cnc5ccccc5n4

InChI

1S/C19H21N3O/c23-18(17-11-20-15-3-1-2-4-16(15)21-17)22-19-8-12-5-13(9-19)7-14(6-12)10-19/h1-4,11-14H,5-10H2,(H,22,23)/t12-,13+,14-,19-

InChI key

ZKFVOZCCAXQXBU-KRFSREQESA-N

生化/生理作用

Type I metabotropic glutamate receptor antagonist

法律信息

Sold with the permission of NPS Pharmaceuticals, Inc. striclty for in vitro use only.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

063K4710

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Structure-activity relationship studies of NPS 2390: A potent and selective group I metabotropic glutamate receptor antagonist.

Van Wagenen, B.C., et al.

Abstr. Soc. Neurosci, #618.3 (2000)

Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells.

Nicola Antonio Martino et al.

PloS one, 6(3), e17714-e17714 (2011-03-26)

The present study investigates the effects of high external calcium concentration ([Ca(2+)](o)) and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines. The involvement of

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.

Charalambos Kaittanis et al.

The Journal of experimental medicine, 215(1), 159-175 (2017-11-17)

Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in

Calcium-sensing receptor-mediated osteogenic and early-stage neurogenic differentiation in umbilical cord matrix mesenchymal stem cells from a large animal model.