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Merck

N4413

Sigma-Aldrich

Anti-Nanog antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-FLJ12581, Anti-Nanog homeobox

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

种属反应性

human

浓度

~1 mg/mL

技术

western blot: 1:1,000-1:2,000

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... NANOG(79923)
mouse ... Nanog(71950)
rat ... Nanog(414065)

一般描述

Nanog homeobox (NANOG) is a 305 amino acid transcription factor. It is expressed in many types of cancers.

免疫原

synthetic peptide corresponding to an internal sequence of human Nanog.

生化/生理作用

Nanog homeobox (NANOG) works with pluripotency factors like sex determining region Y-box 2 (SOX2). It is involved in conserving the pluripotency and self-renewal properties of embryonic stem cells. NANOG also associates with the c-Jun promoter.

外形

solution in phosphate buffered saline, containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

NANOG upregulates c-Jun oncogene expression through binding the c-Jun promoter.
Lin Y
Molecular Carcinogenesis, 54(11), 1407-1416 (2015)
Shuai Gong et al.
Molecular carcinogenesis, 54(9), 679-687 (2015-05-28)
As one of the key pluripotency transcription factors, NANOG plays a critical role in maintaining the self-renewal and pluripotency in normal embryonic stem cells. Recent data indicate that NANOG is expressed in a variety of cancers and its expression correlates
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Hayashi Y
Proceedings of the National Academy of Sciences of the USA, 112(15), 4666-4671 (2015)

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