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About This Item
经验公式（希尔记法）:
C11H17N5O2
CAS号:
分子量:
251.28
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
化驗
≥98% (HPLC)
形狀
solid
顏色
lavender
mp
252.5-253.7 °C (lit.)
溶解度
DMSO: 15 mg/mL
儲存溫度
2-8°C
SMILES 字串
O=NC1=C(N)N=C(N)N=C1OCC2CCCCC2
InChI
1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
InChI 密鑰
DGWXOLHKVGDQLN-UHFFFAOYSA-N
基因資訊
human ... CDK2(1017) , MGMT(4255)
生化／生理作用
NU6027 is a potent inhibitor of ATR signalling
Selective cyclin-dependent kinase-2 (CDK2) inhibitor.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
A Peasland et al.
British journal of cancer, 105(3), 372-381 (2011-07-07)
The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been recognised as an important target for cancer
Rebeka Sultana et al.
PloS one, 8(2), e57098-e57098 (2013-03-02)
Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair and base
Jie Chen et al.
DNA repair, 73, 55-63 (2018-11-25)
The ataxia telangiectasia-mutated and Rad3-related (ATR) serine/threonine kinase plays a central role in the repair of replication-associated DNA damage, the maintenance of S and G2/M-phase genomic stability, and the promotion of faithful mitotic chromosomal segregation. A number of stimuli activate
Sarah Akbib et al.
PloS one, 14(2), e0212210-e0212210 (2019-02-20)
Cell therapy for diabetes could benefit from the identification of small-molecule compounds that increase the number of functional pancreatic beta cells. Using a newly developed screening assay, we previously identified glucocorticoids as potent stimulators of human and rat beta cell
Benjamin A Hilton et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(9), 3882-3893 (2017-05-19)
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is caused by a point mutation in the LMNA gene, resulting in production of a truncated farnesylated-prelamin A protein (progerin). We previously reported that XPA mislocalized to the progerin-induced DNA
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