跳转至内容
Merck
所有图片(1)

文件

N0756

Sigma-Aldrich

N-亚硝基二乙胺

liquid, nitrosamine

别名:

二乙基亚硝胺

登录查看公司和协议定价
所有图片(1)

About This Item

线性分子式:
(C2H5)2NNO
CAS号:
55-18-5
分子量:
102.14
Beilstein:
1744991
EC號碼:
200-226-1
MDL號碼:
MFCD00013890
分類程式碼代碼:
12352116
PubChem物質ID:
24897440
NACRES:
NA.77

product name

N-亚硝基二乙胺, liquid

形狀

liquid

顏色

yellow

bp

177 °C (lit.)

密度

0.95 g/mL (lit.)

SMILES 字串

CCN(CC)N=O

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

InChI 密鑰

WBNQDOYYEUMPFS-UHFFFAOYSA-N

正在寻找类似产品? 访问 产品对比指南

一般說明

N-亚硝基二乙胺属于亚硝胺类含氮消毒副产物。用氯消毒的水处理设备中也能产生这种副产物。

應用

N-亚硝基二乙胺已用于诱发大鼠和小鼠的肝细胞癌发生。

生化／生理作用

N-亚硝基二乙胺(NDMA)对于所有受试动物物种都是致癌物。主要靶器官是鼻腔、气管、肺、食道和肝脏。NDMA通过作用于细胞色素P450系统而导致致癌物甲基重氮离子的产生。但假单胞菌等微生物可将NDMA代谢为N-硝基甲胺(NTMA)和甲醛。

包裝

批量包装

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險聲明

H301,H350,H412

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

其他客户在看

Slide 1 of 2

1 of 2

N-亚硝基二乙胺 (NDEA) Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2408

N-亚硝基二乙胺 (NDEA)

TCPOBOP ≥98% (HPLC), solid

Sigma-Aldrich

T1443

TCPOBOP

Effects of heavy metal ions on N-nitrosodimethylamine (NDMA) formation
Liu Y, et al.
Royal Society of Chemistry Advances, 6(74), 70474-70479 (2016)
Jun Ho Lee et al.
EBioMedicine, 58, 102926-102926 (2020-08-03)
High recurrence and chemoresistance drive the high mortality in hepatocellular carcinoma (HCC). Although cancer stem cells are considered to be the source of recurrent and chemoresistant tumors, they remain poorly defined in HCC. Tonicity-responsive enhancer binding protein (TonEBP) is elevated
Occurrence and control of N-nitrosodimethylamine in water engineering systems
Bian Y, et al.
Environmental Engineering Research, 24(1), 1-16 (2018)
Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development
Sarris ME, et al.
Cancer Cell, 29(3), 354-366 (2016)
Diane Fournier et al.
Applied and environmental microbiology, 72(10), 6693-6698 (2006-09-05)
N-Nitrosodimethylamine (NDMA) is a potent carcinogen and an emerging contaminant in groundwater and drinking water. The metabolism of NDMA in mammalian cells has been widely studied, but little information is available concerning the microbial transformation of this compound. The objective
查看所有相关文献

商品

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门