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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
浓度
1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2.5-7 μg/mL using human tissue
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... MC1R(4157)
mouse ... Mc1r(17199)
一般描述
Anti-Melanocortin 1 Receptor is produced in rabbit using as immunogen a synthetic peptide conjugated to KLH. The peptide corresponds to the third cytoplasmic loop of human Melanocortin 1 Receptor. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.
Anti-Melanocortin 1 Receptor specifically recognizes human melanocortin 1 receptor by immunohistochemistry in formalin-fixed, paraffin-embedded tissues. Not tested for other uses. The immunizing peptide has 88% homology with the mouse gene. Other species reactivity has not been confirmed. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.
Anti-Melanocortin 1 Receptor specifically recognizes human melanocortin 1 receptor by immunohistochemistry in formalin-fixed, paraffin-embedded tissues. Not tested for other uses. The immunizing peptide has 88% homology with the mouse gene. Other species reactivity has not been confirmed. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.
免疫原
synthetic peptide corresponding to the third cytoplasmic loop of human melanocortin 1 receptor. The immunizing peptide has 88% homology with the mouse gene.
应用
Anti-Melanocortin 1 Receptor antibody produced in rabbit was used in immunoblotting for chondrocyte protein extracts at a dilution of 1:2000.
生化/生理作用
Melanocortin 1 receptor (MC1R) is a G-protein coupled receptor that regulates the proliferation and differentiation of melanocytes. The melanocortin hormones activate MC1R that in turn triggers ERK1/2 pathway that promotes the synthesis of eumelanin pigments. Overexpression of MC1R is reported in a majority of human melanomas and acts as a marker in these tumor.
外形
Solution in phosphate buffered saline containing ≤0.1 % sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Marta Abrisqueta et al.
Journal of cell science, 126(Pt 16), 3724-3737 (2013-06-12)
The melanocortin 1 receptor (MC1R) is a G-protein-coupled receptor (GPCR) crucial for the regulation of melanocyte proliferation and differentiation. MC1R activation by melanocortin hormones triggers the cAMP pathway and stimulates the extracellular-signal-regulated protein kinases ERK1 and ERK2 to promote synthesis
Judit Váradi et al.
PloS one, 12(1), e0170537-e0170537 (2017-01-20)
Alpha-melanocyte-stimulating hormone (α-MSH) is a potent anti-inflammatory peptide with cytoprotective effect in various tissues. The present investigation demonstrates the ability of α-MSH to interact with intestinal epithelial cell monolayers and mitigate inflammatory processes of the epithelial barrier. The protective effect
Magdalena K Kaneva et al.
British journal of pharmacology, 167(1), 67-79 (2012-04-05)
Melanocortin MC(1) and MC(3 ) receptors, mediate the anti-inflammatory effects of melanocortin peptides. Targeting these receptors could therefore lead to development of novel anti-inflammatory therapeutic agents. We investigated the expression of MC(1) and MC(3) receptors on chondrocytes
A A Rosenkranz et al.
Biochemistry. Biokhimiia, 78(11), 1228-1237 (2014-01-28)
The conventional chemotherapeutic treatment of malignant melanoma still remains poorly efficient in most cases. Thus the use of specific features of these tumors for development of new therapeutic modalities is highly needed. Melanocortin 1 receptor (MC1R) overexpression on the cell
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