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Merck

M8759

Sigma-Aldrich

3-马来酰亚胺基苯甲酸 N -羟基琥珀酰亚胺酯

别名:

MBS

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About This Item

经验公式(希尔记法):
C15H10N2O6
CAS号:
分子量:
314.25
Beilstein:
1505254
EC號碼:
MDL號碼:
分類程式碼代碼:
47101511
PubChem物質ID:

mp

175-177 °C (lit.)

溶解度

ethyl acetate or DMF: ≤20 mg/mL (may require addition of solvent to coupling buffer to at least 5% to maintain solubility)

儲存溫度

−20°C

SMILES 字串

O=C1CCC(N1OC(C2=CC=CC(N3C(C=CC3=O)=O)=C2)=O)=O

InChI

1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2

InChI 密鑰

LLXVXPPXELIDGQ-UHFFFAOYSA-N

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應用

对伯胺和巯基具有反应性的双异官能化交联剂。通常,初始反应在 pH 为 7.0 时,通过酰胺键偶联至含伯胺的分子,然后在相同 pH 通过硫醚偶联至含巯基的化合物。用于制备酶免疫交联剂和半抗原载体分子偶联物。

其他說明

芳基马来酰亚胺比烷基马来酰亚胺连接基更不稳定。

取代透過

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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D M Grieger et al.
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This study evaluated the antigenicity of LH-ovalbumin complexes produced using different conjugation techniques. Two homobifunctional cross-linkers, glutaraldehyde (Glut) and carbodiimide (ECDI), were evaluated together with one heterobifunctional reagent, m-maleimido-benzoyl N-hydroxysuccinimide ester (MBS). Polyacrylamide gel electrophoresis and Western transfer techniques were
Y Okamura et al.
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Anti-bilirubin-IX alpha monoclonal antibodies exclusively specific for unconjugated bilirubin-IX alpha are prepared and characterized. Using modified MBS (metamaleimidobenzoyl-N-hydroxysuccinimide ester) method, bilirubin-IX alpha was covalently coupled to bovine serum albumin (BSA) retaining its intramolecular hydrogen bonds as well as three-dimensional structure.
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