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Merck

M8193

Sigma-Aldrich

MADAM dihydrochloride

别名:

2-(2′-Amino-4′-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride

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About This Item

经验公式(希尔记法):
C16H22Cl2N2S
分子量:
345.33
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

形狀

solid

儲存條件

desiccated
protect from light
under inert gas

顏色

white

溶解度

H2O: ~18 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cl[H].Cl[H].CN(C)Cc1ccccc1Sc2ccc(C)cc2N

InChI

1S/C16H20N2S.2ClH/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3;;/h4-10H,11,17H2,1-3H3;2*1H

InChI 密鑰

GSBZMNLLLNHKDY-UHFFFAOYSA-N

生化/生理作用

High affinity ligand for the serotonin transporter SERT

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Patrick Emond et al.
Journal of medicinal chemistry, 45(6), 1253-1258 (2002-03-08)
A series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepinephrine transporters. The examination of K(i) values revealed that most of
Sylvie Chalon et al.
The Journal of pharmacology and experimental therapeutics, 304(1), 81-87 (2002-12-20)
Serotonin transporter has a key-role in regulation of serotoninergic function, and is involved in numerous neurodegenerative and psychiatric disorders. To obtain an efficient radioactive ligand allowing the study of this transporter in vitro and in vivo, we synthesized a new

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