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Merck

M7782

Sigma-Aldrich

Antiflammin-1

≥97% (HPLC)

别名:

Anti-inflammatory peptide 1, Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser

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About This Item

经验公式(希尔记法):
C45H82N12O14S2
分子量:
1079.33
MDL號碼:
分類程式碼代碼:
12352200

化驗

≥97% (HPLC)

成份

Peptide content, ~70%

儲存溫度

−20°C

SMILES 字串

CSCCC(N)C(=O)NC(CCC(N)=O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CO)C(O)=O

生化/生理作用

Inhibits synthesis of platelet activating factor.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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David B Rivers et al.
Toxicon : official journal of the International Society on Toxinology, 40(1), 9-21 (2001-10-17)
The mode of action of venom from the ectoparasitic wasp Nasonia vitripennis in eliciting cell death was examined using an in vitro approach with BTI-TN-5B1-4 cells, and the cell responses were compared to those evoked by the extensively studied wasp
Jianzhong Han et al.
Cell biology international, 32(9), 1108-1115 (2008-06-11)
Antiflammin-1 (AF-1) is a synthetic nonapeptide with a similar sequence to the conserved sequence of CC10 secreted by lung Clara cells. Studies suggest that it is potent inhibitor of inflammation. We investigated the effects and possible mechanisms of AF-1 on
N K Mize et al.
Experimental dermatology, 6(4), 181-185 (1997-08-01)
The potential of an anti-inflammatory peptide (antiflammin 1) to reduce irritation when delivered transdermally by iontophoresis was examined. A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally. Quantitative skin irritation
M Marastoni et al.
Arzneimittel-Forschung, 41(3), 240-243 (1991-03-01)
The nonapeptide H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH (antiflammin), corresponding to a high amino acid similarity region of uteroglobin was prepared by solution and solid phase synthesis. The peptide do not inhibit pancreatic phospholipase A2 in vitro and the carrageenin-induced oedema in vivo.
Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions.
G Camussi et al.
Advances in experimental medicine and biology, 279, 161-172 (1990-01-01)

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