化驗
≥98% (TLC)
SMILES 字串
CCCc1c(O)c(ccc1OCCCCc2nnn[nH]2)C(C)=O
InChI
1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)
InChI 密鑰
MWYHLEQJTQJHSS-UHFFFAOYSA-N
生化／生理作用
Selective leukotriene D4 (LTD4) receptor antagonist; PPARα and PPARγ agonist.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
N L Anderson et al.
Toxicology and applied pharmacology, 137(1), 75-89 (1996-03-01)
We have investigated the effects of five peroxisome proliferators (PPs : clofibric acid, DEHP, WY14,643, nafenopin, and LY171883) on the abundances of a large number of proteins in the livers of treated mice at 5- and 35-day time points. LY171883
Furosemide attenuates bronchial responsiveness to antigen challenge "in vitro".
G Folco et al.
Advances in prostaglandin, thromboxane, and leukotriene research, 23, 365-367 (1995-01-01)
K Yamakawa et al.
Biochemical and biophysical research communications, 271(3), 571-574 (2000-05-18)
Vascular endothelial growth factor (VEGF), expressed in a variety of mesenchymal cells including vascular smooth muscle cells (VSMC), is a potent mitogen for endothelial cells, and is used clinically applied for ischemic disease of peripheral vessels. To determine whether peroxisome
T S Rao et al.
The Journal of pharmacology and experimental therapeutics, 269(3), 917-925 (1994-06-01)
Intraperitoneal administration of zymosan to mice resulted in marked biosynthesis of eicosanoids and influx of neutrophils with distinct time course profiles. 6-Keto-prostaglandin-F1 alpha (6-KPA) increased between 30 and 60 min and rapidly decreased thereafter. Leukotriene (LT)C4 levels showed similar patterns
Ingalill Avis et al.
Cancer research, 65(10), 4181-4190 (2005-05-19)
Arachidonic acid (AA) metabolizing enzymes and peroxisome proliferator-activated receptors (PPARs) have been shown to regulate the growth of epithelial cells. We have previously reported that exposure to the 5-lipoxygenase activating protein-directed inhibitor MK886 but not the cyclooxygenase inhibitor, indomethacin, reduced
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