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Merck
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主要文件

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L5386

Sigma-Aldrich

[des-Gly10, D-Trp6]-LH-RH ethylamide

≥97% (HPLC)

别名:

Deslorelin

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About This Item

经验公式（希尔记法）:
C64H83N17O12
CAS号:
57773-65-6
分子量:
1282.45
MDL编号:
MFCD00167401
UNSPSC代码:
12352200
PubChem化学物质编号:
329817623

方案

≥97% (HPLC)

UniProt登记号

P55248
P01148
P07490
P13562
P30968
P30969
Q01776

储存温度

−20°C

SMILES字符串

CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CO)NC(=O)[C@H](Cc5c[nH]c6ccccc56)NC(=O)[C@H](Cc7c[nH]cn7)NC(=O)[C@@H]8CCC(=O)N8

InChI

1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1

InChI key

GJKXGJCSJWBJEZ-XRSSZCMZSA-N

基因信息

human ... GNRH1(2796) , GNRHR(2798)
mouse ... GNRH1(14714) , GNRHR(14715)
rat ... GNRH1(25194) , GNRHR(81668)

Amino Acid Sequence

pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt

生化/生理作用

Long-acting LH-RH agonist.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360

预防措施声明

P201 - P308 + P313

危险分类

Repr. 1B

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
118H0507
088H0900
088H09001
055H0642
049H1300

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S A Colgan et al.
Australian veterinary journal, 97(12), 515-523 (2019-11-21)
A large-scale capture method was developed to enable sterilisation of a macropod population in western Sydney from 2005 to 2018. Until March 2007, free ranging eastern grey kangaroos and red kangaroos were herded into purpose-built 15 m diameter capture yards
Robert M Kirberger et al.
BMC veterinary research, 13(1), 312-312 (2017-11-08)
Cheetahs in captivity have a high prevalence of chronic renal diseases. We ultrasonographically evaluated the renal volumes, a variety of renal dimensions, interarcuate artery resistive indices (RI) as well as aortic diameters and the length of the ventral aspect of the
Wojciech Niżański et al.
Animals : an open access journal from MDPI, 10(12) (2020-12-17)
This article presents B-mode and color Doppler imaging of the prostate and testes in dogs suffering from benign prostate hyperplasia (BPH), and receiving deslorelin acetate (SuprelorinTM) or osaterone acetate (YpozaneTM). The study was planned as a controlled clinical trial, dogs
L David Mech et al.
PloS one, 12(9), e0184342-e0184342 (2017-09-02)
Following the production of western gray wolf (Canis lupus) x western coyote (Canis latrans) hybrids via artificial insemination (AI), the present article documents that the hybrids survived in captivity for at least 4 years and successfully bred with each other.
Marta Cecchetto et al.
Journal of feline medicine and surgery, 19(12), 1224-1230 (2017-02-15)
Objectives The purpose of this study was to assess efficacy of deslorelin, a gonadotropin-releasing hormone (GnRH) agonist marketed in Europe for the control of male dog reproduction, for the postponement of puberty in queens. Methods Nine prepubertal queens aged 3-9
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