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Merck

L4420

Sigma-Aldrich

LY-367385 盐酸盐

≥98% (HPLC)

别名:

(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid

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About This Item

经验公式(希尔记法):
C10H11NO4 ·HCl
分子量:
245.66
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to off-white

溶解度

H2O: >10 mg/mL

起源

Eli Lilly

儲存溫度

room temp

SMILES 字串

Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O

InChI

1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

InChI 密鑰

SGIKDIUCJAUSRD-QMMMGPOBSA-N

應用

LY-367385 hydrochloride has been used as a non-N-methyl-D-aspartate (NMDA) glutamate receptor blocker in neuronal stimulation experiment.

生化/生理作用

LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).
LY-367385 is a selective metabotropic glutamate 1a receptor (mGlu1a) antagonist.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
Bonsi P, et al.
Neuropharmacology, 49(5), 104-113 (2005)
Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network
Lautz JD, et al.
Journal of Neurochemistry, 146(5), 540-559 (2018)
D Y Sakae et al.
Molecular psychiatry, 20(11), 1448-1459 (2015-08-05)
Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine and glutamate as neurotransmitters. The respective roles of each
Miseon Kang et al.
Scientific reports, 10(1), 17921-17921 (2020-10-23)
Abnormally increased neuronal activity in the lateral habenula (LHb) is closely associated with depressive-like behavior. Despite the emphasis on the pathological importance of NMDA receptor (NMDAR)-dependent long-term depression (LTD) and the involvement of calcium permeable AMPA receptor (CP-AMPAR) as major
Michelle Corkrum et al.
Neuron, 105(6), 1036-1047 (2020-01-20)
Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using

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