L2545

LY225910

≥98% (HPLC)

• 别名: 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy )phenyl]-4-(3H)-quinazolinone
• 经验公式（希尔记法）: C₂₇H₂₄BrN₃O₂
• CAS号: 133040-77-4
• 分子量: 502.40
• MDL號碼: MFCD00907856
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329817399
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: off-white
• 溶解度: DMSO: >20 mg/mL
• 起源: Eli Lilly
• 儲存溫度: 2-8°C
• SMILES 字串: CC(C)Oc1cccc(c1)N2C(CCc3c[nH]c4ccc(Br)cc34)=Nc5ccccc5C2=O
• InChI: 1S/C27H24BrN3O2/c1-17(2)33-21-7-5-6-20(15-21)31-26(30-25-9-4-3-8-22(25)27(31)32)13-10-18-16-29-24-12-11-19(28)14-23(18)24/h3-9,11-12,14-17,29H,10,13H2,1-2H3
• InChI 密鑰: KUECXUACQOYKNB-UHFFFAOYSA-N

说明

生化／生理作用

Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission.

LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia.

特點和優勢

This compound is featured on the Cholecystokinin and Gastrin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H413
• 防範說明: P264 - P270 - P273 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral - Aquatic Chronic 4
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 638.6 - 762.1 °F
• 閃點（°C）: 337 - 405.6 °C