方案
~85% (TLC)
表单
crystalline
溶解性
DMSO: soluble
methanol: soluble
储存温度
−20°C
SMILES字符串
OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3cc(O)ccc3O
InChI
1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28)
InChI key
ULTTYPMRMMDONC-UHFFFAOYSA-N
基因信息
human ... EGFR(1956) , ERBB2(2064) , LCK(3932)
生化/生理作用
Cell-permeable tyrosine kinase inhibitor with little effect on protein kinase A or C. Inhibits NMDA-stimulated cGMP production. Inhibits VEGF-induced angiogenesis.
外形
Photosensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
D Spicarova et al.
Neuroscience, 166(1), 305-311 (2009-12-17)
Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. Insulin receptors (IRs) are known to
C C Huang et al.
The Journal of physiology, 520 Pt 3, 783-796 (1999-11-02)
1. Protein tyrosine phosphorylation is thought to play an important role in the regulation of neuronal function. Previous work has shown that protein tyrosine kinase (PTK) inhibitors can inhibit the induction of long-term potentiation (LTP), a candidate synaptic mechanism involved
Marek Opałka et al.
Reproductive biology, 6 Suppl 2, 47-54 (2007-01-16)
The mechanism of phytoestrogen action in gonadal cells of ganders has not been elucidated. The aim of the study was to investigate in Biłgoraj ganders the possibility of phytoestrogen action via estrogen or androgen receptors or via protein tyrosine kinase
Kristin Löber et al.
Journal of cellular biochemistry, 103(4), 1076-1088 (2007-07-31)
The human mast cell line (HMC-1(560)) was used to study the effects of tyrosine kinase (TyrK) inhibition on histamine release in consequence of intracellular Ca2+ or pH changes. This is important since the TyrK inhibitor STI571 (Glivec) inhibits proliferation and
Shi-Sheng Zhou et al.
Experimental physiology, 92(3), 549-559 (2007-02-17)
The effects of monocarboxylic acid-derived Cl(-) channel blockers on cardiac depolarization-activated K(+) currents were investigated. Membrane currents in rat ventricular myocytes were recorded using the whole-cell configuration of the patch-clamp technique. 5-Nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and niflumic acid (NFA) induced an
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