方案
≥98% (HPLC)
表单
powder
溶解性
DMSO: >10 mg/mL
储存温度
room temp
SMILES字符串
Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccnc4cc(Cl)ccc34
InChI
1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
InChI key
GIEHIZKCIZLXLF-UHFFFAOYSA-N
生化/生理作用
KM11060 is a mutated F508del CFTR corrector.
KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Caiqi Zhao et al.
PloS one, 8(12), e82683-e82683 (2013-12-25)
Mutation of CFTR (cystic fibrosis transmembrane conductance regulator) leads to cystic fibrosis (CF). Patients with CF develop abnormalities of blood platelets and recurrent lung inflammation. However, whether CFTR-mutated platelets play a role in the development of lung inflammation is elusive.
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