K1377

卡那霉素 硫酸酯 来源于卡那霉素链霉菌

powder, BioReagent, suitable for cell culture, suitable for plant cell culture

• 别名: 卡那霉素 A, 卡那霉素碱 硫酸盐
• 经验公式（希尔记法）: C₁₈H₃₆N₄O₁₁ · H₂O₄S
• CAS号: 25389-94-0
• 分子量: 582.58
• EC號碼: 246-933-9
• MDL號碼: MFCD00070253
• 分類程式碼代碼: 51281654
• PubChem物質ID: 24896204
• NACRES: NA.76

属性

• 生物源: Streptomyces kanamyceticus
• 品質等級: 200
• 產品線: BioReagent
• 形狀: powder
• 效力: ≥750 μg per mg (dry basis)
• 技術: cell culture | mammalian: suitable; cell culture | plant: suitable
• 顏色: white to off-white
• 溶解度: H₂O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; mycoplasma
• 應用: agriculture
• 作用方式: protein synthesis | interferes
• SMILES 字串: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
• InChI 密鑰: OOYGSFOGFJDDHP-KMCOLRRFSA-N

说明

一般說明

在生物技术中用于抑制蛋白质合成。建议以 100mg/L 的量用于细胞培养应用。

Chemical structure: aminoglycoside

應用

Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media.

生化／生理作用

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。

耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。

抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

注意

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

準備報告

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H360D
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)