推荐产品
生物源
goat
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
human
技術
neutralization: suitable
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... IL10(3586)
一般說明
Interleukin 10 is located on human chromosome 1q32.1.
Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. The production of IL-10 is mediated by signalling of IL-6, IL-12 and TGF-β. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10 is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10 production is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Anti-interleukin-10 antibody is specific for human IL-10. The antibody shows ~7% cross reactivity with recombinant mouse IL-10 in ELISA and immunoblotting.
Anti-interleukin-10 antibody is specific for human IL-10. The antibody shows ~7% cross reactivity with recombinant mouse IL-10 in ELISA and immunoblotting.
特異性
The antibody neutralizes the biological activity of recombinant human IL-10, but not recombinant mouse IL-10.
免疫原
recombinant human IL-10 expressed in Sf 21 insect cells.
應用
Anti-interleukin 10 antibody produced in goat has been used to measure the anti-allodynic effect of IL-10 in the neuropathic pain rat model.
Anti-interleukin-10 antibody may be used for immunoblotting at a working concentration of 1 μg/ml. For ELISA a working concentration of 0.25 μg/ml is recommended. The antibody is suitable for neutralization reactions. This antibody has also been used for immunohistochemistry of cervicovaginal epithelial cells of rabbit
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
生化／生理作用
Interleukin 10 (IL10) helps to induce anti-tumor immune response. It controls tumor tolerance in non-small cell lung cancer. IL10 prevents the synthesis of pro-inflammatory cytokines by activating the JAK/STAT (janus kinase/signal transducers and activators of transcription) signalling pathway.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
準備報告
Purified using protein G.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Interleukin-10-regulated tumour tolerance in non-small cell lung cancer.
Vahl JM, et al.
British Journal of Cancer, 117(11), 1644-1644 (2017)
Sadhana M Gupta et al.
Mediators of inflammation, 2008, 534532-534532 (2009-01-07)
Topical microbicides are intended for frequent use by women in reproductive age. Hence, it is essential to evaluate their impact on mucosal immune function in the vagina. In the present study, we evaluated nisin, a naturally occurring antimicrobial peptide (AMP)
Chlamydia trachomatis inhibits the production of pro-inflammatory cytokines in human PBMCs through induction of IL-10.
Du K, et al.
Journal of Medical Microbiology, 67(2), 240-248 (2018)
Genetic associations of the interleukin locus at 1q32. 1 with clinical outcomes of cutaneous melanoma.
Rendleman J, et al.
Journal of medical Genetics, 52(4), 231-239 (2015)
Byung-Sang Lee et al.
Journal of Korean medical science, 28(2), 308-314 (2013-02-13)
We examined the possible anti-inflammatory mechanisms of gabapentin in the attenuation of neuropathic pain and the interaction between the anti-allodynic effects of gabapentin and interleukin-10 (IL-10) expression in a rat model of neuropathic pain. The anti-allodynic effect of intrathecal gabapentin
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