推荐产品
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥98% (SDS-PAGE)
形狀
lyophilized powder
效力
≤2.0 ng/mL ED50
分子量
31 kDa
包裝
pkg of 50 μg
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... IL17A(3605)
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生化／生理作用
IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
外觀
Lyophilized with no additives.
分析報告
- The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
- Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
W T Qi et al.
Genetics and molecular research : GMR, 14(4), 13364-13369 (2015-11-05)
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were
Lin Fan et al.
PloS one, 10(5), e0127087-e0127087 (2015-05-29)
Th1 cells play an essential role in immune protection against tuberculosis. Th17 cells might be involved with immune pathology in active human tuberculosis (TB). The balance between Th1 and Th17 cells in patients with cavitary tuberculosis needs to be clarified
Yan Jin et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 52(10), 981-988 (2015-08-25)
There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time. This work aims to present a clearer relationship between asthma and the polymorphisms of IL-17A and IL-17F. Searches
J Y Wang et al.
Allergy, 64(7), 1056-1060 (2009-02-13)
The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of
Thomas Fabre et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3925-3933 (2014-09-12)
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have
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